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KMID : 1038920210200010032
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Annals of Optometry and Contact Lens
2021 Volume.20 No. 1 p.32 ~ p.38
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Correlation between Ocular Surface Staining Score and Serum Vitamin D in Sjogren’s and Non-Sjogren’s Syndrome
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Gong Ye-Seul
Kang Kui-Dong
Kim Hyun-Seung
Hwang Hyung-Bin
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Abstract
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Purpose: To analyze the correlation between the ocular surface staining score (OSS) and serum vitamin D level for patients of Sjogren's syndrome (group A) and non-Sjogren's syndrome (group B) with dry eye symptoms.
Methods: In this observational cross-sectional study, The Schirmer I test, OSS, tear film break-up time and serum vitamin D level were measured in 65 eyes of 65 adults complaining of dry eye. Among 65 people, 35 people in group A and 30 people in group B. The Student’s t-test was used for analyzing the ocular surface staining respectively, in group A and group B patients. Pearson’s correlation was used to analyze the correlations of OSS with serum vitamin D level.
Results: The serum vitamin D level (rho = -0.245, p = 0.049) was negatively correlated with OSSs. Especially, the serum vitamin D level (rho = -0.440, p = 0.008) was significantly negatively correlated with OSSs in Sjogren's syndrome patients even more than total patient group.
Conclusions: This suggests that the OSS is highly related to immunological factors such as vitamin D in dry eyes due to an underlying immunological disease. Finding the exact relationship between the inducer of dry eye and the degree of dry eye and clarifying the correlation seems to play an important role in the direction of treatment for dry eye.
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KEYWORD
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Dry eye syndrome, Keratoconjunctivitis sicca, Ocular staining score, Sjogren’s syndrome, Vitamin D
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